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Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome
Shea J. Andrews
1 ,
Brian Fulton‐Howard
1 ,
Paul O'Reilly
2
,
3 ,
Edoardo Marcora
1 ,
Alison M. Goate
1
,
2 ,
Lindsay A. Farrer ,
Jonathan L. Haines ,
Richard Mayeux ,
Adam C. Naj ,
Margaret A. Pericak‐Vance ,
Gerard D. Schellenberg ,
Li‐San Wang ,
collaborators of the Alzheimer's Disease Genetics Consortium
October 15 2020
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Abstract
The purpose of this study was to infer causal relationships between 22 previously
reported risk factors for Alzheimer's disease (AD) and the "AD phenome": AD, AD age
of onset (AAOS), hippocampal volume, cortical surface area and thickness, cerebrospinal
fluid (CSF) levels of amyloid-β (Aβ42 ), tau, and ptau181 , and the neuropathological
burden of neuritic plaques, neurofibrillary tangles (NFTs), and vascular brain injury
(VBI).