50
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

      , , , ,
      Immunity
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Related collections

          Most cited references132

          • Record: found
          • Abstract: found
          • Article: not found

          Microbiota-mediated colonization resistance against intestinal pathogens.

          Commensal bacteria inhabit mucosal and epidermal surfaces in mice and humans, and have effects on metabolic and immune pathways in their hosts. Recent studies indicate that the commensal microbiota can be manipulated to prevent and even to cure infections that are caused by pathogenic bacteria, particularly pathogens that are broadly resistant to antibiotics, such as vancomycin-resistant Enterococcus faecium, Gram-negative Enterobacteriaceae and Clostridium difficile. In this Review, we discuss how immune- mediated colonization resistance against antibiotic-resistant intestinal pathogens is influenced by the composition of the commensal microbiota. We also review recent advances characterizing the ability of different commensal bacterial families, genera and species to restore colonization resistance to intestinal pathogens in antibiotic-treated hosts.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The maternal microbiota drives early postnatal innate immune development.

            Postnatal colonization of the body with microbes is assumed to be the main stimulus to postnatal immune development. By transiently colonizing pregnant female mice, we show that the maternal microbiota shapes the immune system of the offspring. Gestational colonization increases intestinal group 3 innate lymphoid cells and F4/80(+)CD11c(+) mononuclear cells in the pups. Maternal colonization reprograms intestinal transcriptional profiles of the offspring, including increased expression of genes encoding epithelial antibacterial peptides and metabolism of microbial molecules. Some of these effects are dependent on maternal antibodies that potentially retain microbial molecules and transmit them to the offspring during pregnancy and in milk. Pups born to mothers transiently colonized in pregnancy are better able to avoid inflammatory responses to microbial molecules and penetration of intestinal microbes.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              T cell metabolism drives immunity

              Buck et al. discuss the role of lymphocyte metabolism on immune cell development and function.
                Bookmark

                Author and article information

                Journal
                Immunity
                Immunity
                Elsevier BV
                10747613
                March 2017
                March 2017
                : 46
                : 3
                : 350-363
                Article
                10.1016/j.immuni.2017.03.009
                28329702
                42135a54-21e6-42c9-8969-84f475ca9e1b
                © 2017
                History

                Comments

                Comment on this article