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      TRH Stimulation of in vivo GH Release in the Domestic Fowl

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          Abstract

          Thyrotropin-releasing hormone (TRH) stimulated in vivo growth hormone (GH) release in conscious and anesthetized young domestic fowl. The administration of the presumed metabolites of TRH, deamido-TRH (TRH-OH) and histidyl-proline diketopiperazine (HPD), was followed by small but significant (p < 0.05) increases in the plasma concentrations of GH in both conscious and anesthetized chicks. However, the ability of TRH-OH or HPD to stimulate GH secretion was less than that observed with a 100-fold lower dose of TRH. The administration of either TRH-OH or HPD with TRH increased the GH response over that observed with TRH alone. The ability of chicken plasma to degrade exogenous TRH in vitro was determined by measuring immunoreactive TRH (IR-TRH) content and by assessing the ability of the incubated samples to increase the plasma concentration of GH when administered to young fowl. The in vitro half-life of TRH was estimated to be 9.8 (by immunoassay) and 9.6 (by a biological index) min for plasma from adult male chickens and 23.9 (by immunoassay) and 20.2 (by biological index) min for plasma from 6-week-old chicks. This difference in degradation may account, at least in part, for the observed age-related decrease in the plasma concentration of GH in birds and for the diminished GH responsiveness of adult birds to exogenous TRH.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1985
          1985
          28 March 2008
          : 40
          : 1
          : 33-38
          Affiliations
          aDepartment of Animal Sciences, Rutgers – The State University, New Brunswick, N.J., USA; bWolfson Institute, University of Hull, England; cDepartment of Physiology, Tufts University School of Medicine, Boston, Mass., USA
          Article
          124048 Neuroendocrinology 1985;40:33–38
          10.1159/000124048
          3918278
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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