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The aim of this study was to investigate the efficacy and safety of bepridil (a multichannel
blocker including several potassium channels) for conversion of long-lasting atrial
fibrillation (AF). Bepridil restored sinus rhythm alone or in combination with aprindine
in 69% of 32 patients with persistent AF lasting > or = 3 months. The time to conversion
after starting bepridil was 30 +/- 12 days. An increase in fibrillation cycle length
with bepridil was greater in responders (31 +/- 10%), but an increase in QTc did not
differ between responders and nonresponders. Bepridil is effective and safe for terminating
long-lasting persistent AF.