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      Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol

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          Abstract

          Fospropofol, a phosphorylated prodrug version of the popular induction agent propofol, is hydrolyzed in vivo to release active propofol, formaldehyde, and phosphate. Pharmacodynamic studies show fospropofol provides clinically useful sedation and EEG/bispectral index suppression while causing significantly less respiratory depression than propofol. Pain at the injection site, a common complaint with propofol, was not reported with fospropofol; the major patient complaint was transitory perianal itching during the drug’s administration. Although many clinicians believe fospropofol can safely be given by a registered nurse, the FDA mandated that fospropofol, like propofol, must be used only in the presence of a trained anesthesia provider.

          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2009
          2009
          29 December 2009
          : 5
          : 949-959
          Affiliations
          Department of Anesthesiology, Perioperative Management, and Pain Medicine, University of Miami/Miller School of Medicine
          Author notes
          Correspondence: David A Lubarsky Emanuel M Papper Professor and Chair, Department of Anesthesiology, Perioperative Management, and Pain Medicine, University of Miami/Miller School of Medicine, 1611 NW 12th Ave, Miami, FL 33136, USA, Email dlubarsky@ 123456med.miami.edu
          Article
          tcrm-5-949
          2801588
          20057894
          4231292e-3ad3-4b4e-8120-cfe7ec07b695
          © 2009 Harris et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          History
          : 7 December 2009
          Categories
          Review

          Medicine
          monitored anesthesia care,fospropofol,propofol
          Medicine
          monitored anesthesia care, fospropofol, propofol

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