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[Acute pulmonary edema during nicardipine and salbutamol therapy for preterm labor in twin pregnancy].

Journal de gynécologie, obstétrique et biologie de la reproduction

Twins, Albuterol, adverse effects, Female, Gestational Age, Humans, Nicardipine, Adult, Obstetric Labor, Premature, drug therapy, Pregnancy, Pulmonary Edema, chemically induced, Tocolytic Agents

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      We report the case of a 38-year-old parturient at 30 weeks 2 days term of a multiple pregnancy who experienced acute pulmonary edema more than 48 hours after tocolytic treatment with nicardipine and salbutamol. The patient was transferred from a level 1 perinatal center to a level 3 perinatal center by the Grenoble mobile intensive care unit in application of the in utero transfer protocol for preterm labor before 33 weeks with twin pregnancy. This case illustrates the risk of tocolytic treatment and potential adverse effects in the event of preterm labor on twin pregnancy. The question of associating a second tocolytic after failure of the first is also raised.

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