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      Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases.

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      The Journal of clinical investigation
      American Society for Clinical Investigation

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          Abstract

          Fibroproliferative diseases, including the pulmonary fibroses, systemic sclerosis, liver cirrhosis, cardiovascular disease, progressive kidney disease, and macular degeneration, are a leading cause of morbidity and mortality and can affect all tissues and organ systems. Fibrotic tissue remodeling can also influence cancer metastasis and accelerate chronic graft rejection in transplant recipients. Nevertheless, despite its enormous impact on human health, there are currently no approved treatments that directly target the mechanism(s) of fibrosis. The primary goals of this Review series on fibrotic diseases are to discuss some of the major fibroproliferative diseases and to identify the common and unique mechanisms of fibrogenesis that might be exploited in the development of effective antifibrotic therapies.

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          Author and article information

          Journal
          J Clin Invest
          The Journal of clinical investigation
          American Society for Clinical Investigation
          0021-9738
          0021-9738
          Mar 2007
          : 117
          : 3
          Affiliations
          [1 ] Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. twynn@niaid.nih.gov
          Article
          10.1172/JCI31487
          1804380
          17332879
          42578766-75a5-45e2-b960-c3e4d4a15949
          History

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