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Alteration of spontaneous neuronal activity in young adults with non-clinical depressive symptoms.

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      Abstract

      Non-clinical depressive symptoms (nCDSs) are highly prevalent in young adults and may be associated with the risk of developing full-fledged depressive disorders. However, the neural basis underlying nCDSs remains unknown. To explore the alteration of spontaneous brain activity in individuals with nCDSs compared with healthy controls (HCs), we investigated resting-state brain activity using the amplitude of low-frequency fluctuations (ALFF) in subjects with nCDSs (n=17) and HCs (n=20). All subjects were drawn from a sample of 1105 college students participating in a survey assessing depressive symptoms. We determined that nCDSs can lead to reduced ALFF in the right ventral lateral prefrontal cortex (VLPFC) and right dorsolateral prefrontal cortex (DLPFC) and to increased ALFF in the left fusiform, left posterior cerebellum, right cuneus, left inferior parietal lobule, right supramarginal gyrus and bilateral precuneus. In addition, with respect to Beck Depression Inventory (BDI) scores and ALFF values in subjects with nCDSs, a positive correlation was discovered in the right DLPFC, while a negative correlation was identified in left posterior cerebellum and bilateral precuneus after correction. These results indicate that nCDSs are characterized by altered spontaneous activity in several important functional regions. We suggest that altered ALFFs in the right DLPFC, left posterior cerebellum and bilateral precuneus may be biomarkers that are related to the pathophysiology of nCDSs in young adults.

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      Affiliations
      [1 ] Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, Guangzhou 510180, Guangdong, China. Electronic address: weixinhua.gz@gmail.com.
      [2 ] Department of Neuroradiology, Tiantan Hospital, Capital Medical University, Beijing 100050, China. Electronic address: shenhuicong@126.com.
      [3 ] Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, Guangzhou 510180, Guangdong, China. Electronic address: 153053052@qq.com.
      [4 ] Faculty of Health Management, Guangzhou Medical University, Guangzhou 510180, China. Electronic address: ahuatien@gmail.com.
      [5 ] Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, Guangzhou 510180, Guangdong, China. Electronic address: 292810119@qq.com.
      [6 ] Department of Radiology, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China. Electronic address: 2394674931@qq.com.
      [7 ] Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, Guangzhou 510180, Guangdong, China. Electronic address: weixinhua2007@126.com.
      [8 ] Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, Guangzhou 510180, Guangdong, China. Electronic address: 2000-wxh@163.com.
      [9 ] Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, Guangzhou 510180, Guangdong, China. Electronic address: 15918750488@163.com.
      [10 ] Department of Radiology, Wayne State University, Detroit, MI 48202, United States. Electronic address: jianihu@yahoo.com.
      [11 ] Department of Neurology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, Guangzhou 510180, Guangdong, China. Electronic address: tazyyxwxh@foxmail.com.
      [12 ] Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, Guangzhou 510180, Guangdong, China. Electronic address: weixinhua.hy@gmail.com.
      Journal
      Psychiatry Res
      Psychiatry research
      Elsevier BV
      1872-7123
      0165-1781
      Jul 30 2015
      : 233
      : 1
      26004037
      S0925-4927(15)00096-7
      10.1016/j.pscychresns.2015.04.008

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