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      Novel biodegradable polycaprolactone occlusion device combining nanofibrous PLGA/collagen membrane for closure of atrial septal defect (ASD).

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          Abstract

          The purpose of this report was to develop novel biodegradable occlusion devices for closure of atrial septal defects (ASD). To manufacture the biodegradable occluders, polycaprolactone (PCL) components were first fabricated by a lab-scale micro-injection molding machine. They were then assembled and hot-spot welded into double umbrella-like devices of 50 mm in diameter. A special mechanism at the axis of the occluder was designed to self-lock the occluder after the two umbrellas were expanded. Furthermore, a nanofibrous matrix of poly-D-L-lactide-glycolide (PLGA)/type I collagen blend was produced via electrospinning to develop biodegradable and biomimetic anti-shunt membranes for the occluders. Characterization of the biodegradable PCL occluders was carried out. PCL occluders exhibited mechanical properties comparable to that of commercially available Amplatzer occluders. The sealing capability of biodegradable occluders was found superior to that of Amplatzer occluders. In addition, the cell attachment and spreading of endothelial cells seeded on the PLGA/collagen nanofibrous matrix and the interaction between cells and PLGA/collagen nanofibers were studied. The nanofibrous membranes made of PLGA/collagen were very effective in promoting cell proliferation during culture.

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          Author and article information

          Journal
          Ann Biomed Eng
          Annals of biomedical engineering
          Springer Nature America, Inc
          1573-9686
          0090-6964
          Nov 2011
          : 39
          : 11
          Affiliations
          [1 ] Biomaterials Lab, Mechanical Engineering, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan. shihjung@mail.cgu.edu.tw
          Article
          10.1007/s10439-011-0368-4
          21800202
          4283971e-d47d-4859-9616-fccf3d55fffa

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