4
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview

      review-article
      a , b , b , a , a , a , c , a ,
      Journal of Orthopaedic Translation
      Chinese Speaking Orthopaedic Society
      Allograft, Artificial material, Autograft, Biomaterial, Long-bone segmental defect reconstruction, Tissue engineering, LBSD, long-bone segmental defect, BMP-2 & 4, bone morphogenetic protein-2 & 4, VEGF, Vascular Endothelial Growth Factor, bFGF, basic Fibroblast Growth Factor, TGF-β, Transforming Growth Factor-β, PDGF, Platelet-Derived Growth Factor, FGF-2, Fibroblast Growth Factor-2, sRANKL, soluble RANKL, M-CSF, macrophage colony-stimulating factor, PET/CT, positron emission- and computed tomography, ALP, alkaline phosphatase, htMSCs, human tubal mesenchymal stem cells, rVEGF-A, recombinant vascular endothelial growth factor-A, rhBMP-2, recombinant human bone morphogenetic protein-2, PCL, polycaprolactone, TCP, tricalcium phosphate, rhBMP-7, recombinant human bone morphogenetic protein 7, PDLLA, poly(DL-lactide), β-TCP, β-tricalcium phosphate, PLA, poly(lactic acid), DBM, decalcified bone matrix, PPF, propylene fumarate, poly, (L-lactide-co-D,L-lactide), MSC, autologous mesenchymal stem cells, TEB, combining ceramic block with osteogenic-induced mesenchymal stem cells and platelet-rich plasma , MIC, fresh marrow-impregnated ceramic block, ALLO, partially demineralized allogeneic bone block, BMSC, bone marrow–derived mesenchymal stem cell, rADSC, rabbit adipose-derived mesenchymal stem cell, ADSC, allogenic adipose-derived stem cells, HDB, heterogeneous deproteinized bone, ASC, adipose-derived stem cell, SF, silk fibroin, CS, chitosan, nHA, nano-hydroxyapatite, BV, baculovirus

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Reconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmission. There are four main types of biomaterials including autograft, allograft, artificial material, and tissue-engineered bone. Remarkable progress has been made in LBSD reconstruction biomaterials in the last ten years.

          The translational potential of this article

          Our aim is to summarize recent developments in the divided four biomaterials utilized in the LBSD reconstruction to provide the clinicians with new information and comprehension from the biomaterial point of view.

          Related collections

          Most cited references63

          • Record: found
          • Abstract: found
          • Article: not found

          Scaffolds for Bone Tissue Engineering: State of the art and new perspectives.

          This review is intended to give a state of the art description of scaffold-based strategies utilized in Bone Tissue Engineering. Numerous scaffolds have been tested in the orthopedic field with the aim of improving cell viability, attachment, proliferation and homing, osteogenic differentiation, vascularization, host integration and load bearing. The main traits that characterize a scaffold suitable for bone regeneration concerning its biological requirements, structural features, composition, and types of fabrication are described in detail. Attention is then focused on conventional and Rapid Prototyping scaffold manufacturing techniques. Conventional manufacturing approaches are subtractive methods where parts of the material are removed from an initial block to achieve the desired shape. Rapid Prototyping techniques, introduced to overcome standard techniques limitations, are additive fabrication processes that manufacture the final three-dimensional object via deposition of overlying layers. An important improvement is the possibility to create custom-made products by means of computer assisted technologies, starting from patient's medical images. As a conclusion, it is highlighted that, despite its encouraging results, the clinical approach of Bone Tissue Engineering has not taken place on a large scale yet, due to the need of more in depth studies, its high manufacturing costs and the difficulty to obtain regulatory approval. PUBMED search terms utilized to write this review were: "Bone Tissue Engineering", "regenerative medicine", "bioactive scaffolds", "biomimetic scaffolds", "3D printing", "3D bioprinting", "vascularization" and "dentistry".
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Bone grafts, bone substitutes and orthobiologics: the bridge between basic science and clinical advancements in fracture healing.

            The biology of fracture healing is better understood than ever before, with advancements such as the locking screw leading to more predictable and less eventful osseous healing. However, at times one's intrinsic biological response, and even concurrent surgical stabilization, is inadequate. In hopes of facilitating osseous union, bone grafts, bone substitutes and orthobiologics are being relied on more than ever before. The osteoinductive, osteoconductive and osteogenic properties of these substrates have been elucidated in the basic science literature and validated in clinical orthopaedic practice. Furthermore, an industry built around these items is more successful and in demand than ever before. This review provides a comprehensive overview of the basic science, clinical utility and economics of bone grafts, bone substitutes and orthobiologics.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Additively Manufactured Scaffolds for Bone Tissue Engineering and the Prediction of their Mechanical Behavior: A Review

              Additive manufacturing (AM), nowadays commonly known as 3D printing, is a revolutionary materials processing technology, particularly suitable for the production of low-volume parts with high shape complexities and often with multiple functions. As such, it holds great promise for the fabrication of patient-specific implants. In recent years, remarkable progress has been made in implementing AM in the bio-fabrication field. This paper presents an overview on the state-of-the-art AM technology for bone tissue engineering (BTE) scaffolds, with a particular focus on the AM scaffolds made of metallic biomaterials. It starts with a brief description of architecture design strategies to meet the biological and mechanical property requirements of scaffolds. Then, it summarizes the working principles, advantages and limitations of each of AM methods suitable for creating porous structures and manufacturing scaffolds from powdered materials. It elaborates on the finite-element (FE) analysis applied to predict the mechanical behavior of AM scaffolds, as well as the effect of the architectural design of porous structure on its mechanical properties. The review ends up with the authors’ view on the current challenges and further research directions.
                Bookmark

                Author and article information

                Contributors
                Journal
                J Orthop Translat
                J Orthop Translat
                Journal of Orthopaedic Translation
                Chinese Speaking Orthopaedic Society
                2214-031X
                2214-0328
                08 October 2019
                May 2020
                08 October 2019
                : 22
                : 26-33
                Affiliations
                [a ]Research Center for Human Tissues and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, 518055, China
                [b ]Applied Oral Sciences, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, China
                [c ]Department of Orthopaedic and Traumatology, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
                Author notes
                []Corresponding author. 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, 518055, China. hb.pan@ 123456siat.ac.cn
                Article
                S2214-031X(19)30209-8
                10.1016/j.jot.2019.09.005
                7231954
                32440496
                42864940-9bd9-42d2-8c15-1924bef480f0
                © 2019 Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 5 July 2019
                : 19 August 2019
                : 9 September 2019
                Categories
                Review Article

                allograft,artificial material,autograft,biomaterial,long-bone segmental defect reconstruction,tissue engineering,lbsd, long-bone segmental defect,bmp-2 & 4, bone morphogenetic protein-2 & 4,vegf, vascular endothelial growth factor,bfgf, basic fibroblast growth factor,tgf-β, transforming growth factor-β,pdgf, platelet-derived growth factor,fgf-2, fibroblast growth factor-2,srankl, soluble rankl,m-csf, macrophage colony-stimulating factor,pet/ct, positron emission- and computed tomography,alp, alkaline phosphatase,htmscs, human tubal mesenchymal stem cells,rvegf-a, recombinant vascular endothelial growth factor-a,rhbmp-2, recombinant human bone morphogenetic protein-2,pcl, polycaprolactone,tcp, tricalcium phosphate,rhbmp-7, recombinant human bone morphogenetic protein 7,pdlla, poly(dl-lactide),β-tcp, β-tricalcium phosphate,pla, poly(lactic acid),dbm, decalcified bone matrix,ppf, propylene fumarate,poly, (l-lactide-co-d,l-lactide),msc, autologous mesenchymal stem cells,teb, combining ceramic block with osteogenic-induced mesenchymal stem cells and platelet-rich plasma,mic, fresh marrow-impregnated ceramic block,allo, partially demineralized allogeneic bone block,bmsc, bone marrow–derived mesenchymal stem cell,radsc, rabbit adipose-derived mesenchymal stem cell,adsc, allogenic adipose-derived stem cells,hdb, heterogeneous deproteinized bone,asc, adipose-derived stem cell,sf, silk fibroin,cs, chitosan,nha, nano-hydroxyapatite,bv, baculovirus
                allograft, artificial material, autograft, biomaterial, long-bone segmental defect reconstruction, tissue engineering, lbsd, long-bone segmental defect, bmp-2 & 4, bone morphogenetic protein-2 & 4, vegf, vascular endothelial growth factor, bfgf, basic fibroblast growth factor, tgf-β, transforming growth factor-β, pdgf, platelet-derived growth factor, fgf-2, fibroblast growth factor-2, srankl, soluble rankl, m-csf, macrophage colony-stimulating factor, pet/ct, positron emission- and computed tomography, alp, alkaline phosphatase, htmscs, human tubal mesenchymal stem cells, rvegf-a, recombinant vascular endothelial growth factor-a, rhbmp-2, recombinant human bone morphogenetic protein-2, pcl, polycaprolactone, tcp, tricalcium phosphate, rhbmp-7, recombinant human bone morphogenetic protein 7, pdlla, poly(dl-lactide), β-tcp, β-tricalcium phosphate, pla, poly(lactic acid), dbm, decalcified bone matrix, ppf, propylene fumarate, poly, (l-lactide-co-d,l-lactide), msc, autologous mesenchymal stem cells, teb, combining ceramic block with osteogenic-induced mesenchymal stem cells and platelet-rich plasma, mic, fresh marrow-impregnated ceramic block, allo, partially demineralized allogeneic bone block, bmsc, bone marrow–derived mesenchymal stem cell, radsc, rabbit adipose-derived mesenchymal stem cell, adsc, allogenic adipose-derived stem cells, hdb, heterogeneous deproteinized bone, asc, adipose-derived stem cell, sf, silk fibroin, cs, chitosan, nha, nano-hydroxyapatite, bv, baculovirus

                Comments

                Comment on this article