Influence of verapamil on the pharmacokinetics of oxcarbazepine and of the enantiomers of its 10-hydroxy metabolite in healthy volunteers.

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Abstract

Oxcarbazepine (OXC), a second-generation antiepileptic, and its chiral metabolite 10-hydroxycarbazepine (MHD) are substrates of P-glycoprotein, which can be inhibited by verapamil. This study evaluated the influence of verapamil on the pharmacokinetics of OXC and MHD enantiomers in healthy volunteers.

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Journal ID (iso-abbrev): Eur J Clin Pharmacol

Title: European journal of clinical pharmacology

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1432-1041

ISSN (Print): 0031-6970

Publication date (Electronic): Feb 2016

Volume: 72

Issue: 2

Affiliations

[1 ] Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

[2 ] Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

[3 ] Division of Pharmacology, School of Science, University of Leiden, Leiden, The Netherlands.

[4 ] Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

[5 ] Departamento de Neurologia, Psiquiatria e Psicologia Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

[6 ] Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. lanchote@fcfrp.usp.br.

Article

Publisher Item ID: 10.1007/s00228-015-1970-4

DOI: 10.1007/s00228-015-1970-4

PubMed ID: 26514967

SO-VID: 42955dd3-3086-4a1e-9fe0-0580724c005b

History

Keywords: 10-hydroxycarbazepine,Enantiomers,Oxcarbazepine,P-glycoprotein,Pharmacokinetics

Data availability:

Keywords: 10-hydroxycarbazepine, Enantiomers, Oxcarbazepine, P-glycoprotein, Pharmacokinetics

Influence of verapamil on the pharmacokinetics of oxcarbazepine and of the enantiomers of its 10-hydroxy metabolite in healthy volunteers.

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