A Syndrome of Hyperandrogenism, Insulin Resistance, and Acanthosis nigricans Associated with Polycystic Ovary Syndrome: Clinical and Laboratory Features

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Abstract

We describe an adolescent Japanese girl with acanthosis nigricans and irregular anovulatory menstruation following menarche. Serum LH levels were elevated, whereas serum FSH levels were within normal range. An exaggerated response to LHRH was observed. Further, serum androstenedione levels were markedly elevated. Ultrasonogram revealed bilateral polycystic changes of ovaries. She had a mild degree of insulin resistance. Insulin binding studies using erythrocytes demonstrated a decreased binding capacity of insulin.From the above findings, this patient presents the syndrome consisting of hyperandrogenism, insulin resistance, and acanthosis nigricans and also has clinical and biochemical features compatible with polycystic ovary syndrome.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISBN: 978-3-8055-5262-2

ISBN: 978-3-318-01975-9

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1990

Publication date (Print): 1990

Publication date (Electronic): 02 December 2008

Volume: 33

Issue: Suppl 2

Pages: 27-30

Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan

Article

Publisher ID: 181562 Other ID: Horm Res 1990;33:27–30

DOI: 10.1159/000181562

PubMed ID: 2095357

SO-VID: 42b34ea9-3f39-45ad-9db5-2cfd3b32ee2e

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A Syndrome of Hyperandrogenism, Insulin Resistance, and Acanthosis nigricans Associated with Polycystic Ovary Syndrome: Clinical and Laboratory Features

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Karger: Endocrinology

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