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      Effect of a Low Sodium Diet on Urinary Elimination of Cystine in Cystinuric Children

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          Restriction of sodium intake has been shown to decrease urinary elimination of cystine in adult subjects with cystinuria. This simple therapeutic recommendation may be particularly useful in pediatric patients whose compliance with high fluid ingestion and repeated doses of alkali is usually poor. We studied the effect of sodium intake in 5 cystinuric children (3 males) aged 5.9-9.3 years. Urinary excretion of cystine (x ± SD) was determined at the end of two sequential 1-week periods in which sodium content of diet was modified. Reduction of sodium intake brought about significant decrases in natriuresis (6.0 ± 2.1 vs. 1.5 ± 0.5 mEq/kg/day, p < 0.03) and urine cystine concentration (328.0 ± 190.7 vs. 14.1 ± 7.4 mg/l, p < 0.02) while urine volume output remained unchanged (58.0 ± 36.0 vs. 70.3 ± 33.0 ml/kg/day). These findings confirm that elimination of cystine is highly influenced by sodium intake in cystinuric children and suggest that a low sodium diet may play a key-role in the treatment of pediatric patients with cystinuria.

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          Author and article information

          S. Karger AG
          18 December 2008
          : 71
          : 4
          : 416-418
          aSection of Pediatric Nephrology, Department of Pediatrics, Hospital Central de Asturias and School of Medicine, University of Oviedo, Asturias, and bComplejo Hospitalario de Leon, Spain
          188761 Nephron 1995;71:416–418
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 3
          Original Paper

          Cardiovascular Medicine, Nephrology

          Sodium, dietary, Urinary calculi, Cystinuria


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