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      Autonomic Neural Control of Cardiac Rhythm: The Role of Autonomic Imbalance in the Genesis of Cardiac Dysrhythmia

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          Abstract

          Cardiac dysrhythmias result from abnormalities in rate, regularity, or sequence of cardiac activation, and because of direct actions of the autonomic nervous system upon each of these properties, imbalance in this system may play an important role in the genesis of cardiac dysrhythmia. A canine model has been developed in which the extrinsic innervation of the heart is ablated with the exception of the ventrolateral cardiac nerve. This nerve is distributed primarily to the inferior atrial, AV junctional, and ventricular tissues. Following recovery from surgery, the animal is placed on a treadmill and required to perform strenuous exercise. In all of six animals which sustained repeated exercise testing over periods of 4-12 months, dysrhythmias of varying complexities were elicited. None appeared in parallel experiments conducted in control or sham-operated animals. The dysrhythmias consisted of supraventricular, AV junctional, or ventricular tachycardias with occasional premature atrial or ventricular systoles. The dysrhythmias were not influenced by atropine but were generally controlled by propranolol.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-2437-7
          978-3-318-02033-5
          0008-6312
          1421-9751
          1976
          1976
          29 October 2008
          : 61
          : 1
          : 20-36
          Affiliations
          Department of Physiology, Stritch School of Medicine, Loyola University, Maywood, Ill.
          Article
          169745 Cardiology 1976;61:20–36
          10.1159/000169745
          975122
          © 1976 S. Karger AG, Basel

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          Page count
          Pages: 17
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