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Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy.
Eun Mi Lee
1 ,
Ga Young Park ,
Ki Chun Im ,
Sang Tae Kim ,
Chul-Woong Woo ,
Jin Hwa Chung ,
Ki Soo Kim ,
Jae Seung Kim ,
Young-Min Shon ,
Yeong In Kim ,
Joong Koo Kang
May 2012
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Abstract
The metabolic and biochemical changes that occur during epileptogenesis remain to be determined. (18) F-Fluorodeoxyglucose positron emission tomography (FDG-PET) and proton magnetic resonance spectroscopy ((1) H MRS) are noninvasive techniques that provide indirect information on ongoing pathologic changes. We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS).