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      Nesiritide enhances myocardial protection during the revascularization of acutely ischemic myocardium.

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          Abstract

          Nesiritide, a recombinant human B-type natriuretic peptide, has been used in conjunction with inotropic agents in the management of low cardiac output and pulmonary hypertension following cardiac surgery. However, its independent effects on intraoperative myocardial protection are unknown. This study was, therefore, undertaken to determine whether nesiritide alone could enhance myocardial protection when given intraoperatively in a porcine model simulating urgent coronary artery bypass graft surgery.

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          Author and article information

          Journal
          J Card Surg
          Journal of cardiac surgery
          Wiley
          1540-8191
          0886-0440
          June 3 2009
          : 24
          : 5
          Affiliations
          [1 ] Department of Cardiothoracic Surgery, Boston Medical Center, Boston, MA 02118, USA. harold.lazar@bmc.org
          Article
          JCS865
          10.1111/j.1540-8191.2009.00865.x
          19486217

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