3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Tigecycline pharmacokinetic/pharmacodynamic update.

      1
      The Journal of antimicrobial chemotherapy
      Oxford University Press (OUP)

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This brief review summarizes recently published data on the pharmacokinetics and pharmacodynamics of tigecycline in man. Significant pharmacokinetic data are now available from the studies of infected patients, as is information on tissue distribution. Importantly, drug exposure-response relationships have been established for complicated skin and skin structure infections and intra-abdominal infection. These studies highlight the difficulties of undertaking pharmacodynamic studies in humans where account must be taken of both mixed pathogen infections and the potential impact of surgery. These data help to define the clinical role for tigecycline.

          Related collections

          Author and article information

          Journal
          J. Antimicrob. Chemother.
          The Journal of antimicrobial chemotherapy
          Oxford University Press (OUP)
          1460-2091
          0305-7453
          Sep 2008
          : 62 Suppl 1
          Affiliations
          [1 ] Department of Medical Microbiology, Bristol Centre for Antimicrobial Research and Evaluation, University of Bristol and North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK. alasdair.macgowan@nbt.nhs.uk
          Article
          dkn242
          10.1093/jac/dkn242
          18684702
          43076c39-eee7-4987-983e-7c25869dccd1
          History

          Comments

          Comment on this article