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      A review on Respiratory allergy caused by insects

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      1 , *
      Bioinformation
      Biomedical Informatics
      Allergens, respiratory allergy, insect allergens, Mosquito allergens, ockroach allergens

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          Abstract

          Hypersensitivity or allergy encompasses a wide range of immunological reactions that generally have adverse consequences involving one or many organ systems of the body. Allergens are usually glycoprotein or chemically complex low molecular weight substances. The common allergens include pollen, fungal spores, house dust mite and house dust, animal danders, drugs, foods, insect emanations, and detritus, etc. Information on the role of insects in respiratory allergy is increasing in the literature. There are about 30 million living species of insects. These insects can broadly be classified as stinging insects, biting insects and non-stinging and non-biting insects. All materials form insets namely wings, scales, saliva; dried feces and venom can cause allergic diseases, such as rhinitis, conjunctivitis, asthma and urticaria. There are wide varieties of insects such as moths, butterflies, bees, wasps, hornets, yellow jackets, flies, beetles, cockroaches, and mosquitoes. Exposure to emanations and detritus of these insects may lead to several allergies in some genetically predisposed individuals. Therefore, it is of interest to review allergies caused by various insect’s stings and bites and their adverse effect on the human body.

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          Most cited references15

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          IgE to recombinant allergens Api m 1, Ves v 1, and Ves v 5 distinguish double sensitization from crossreaction in venom allergy.

          Diagnostic tests in patients with Hymenoptera venom allergy are frequently positive to venoms of both honey bee and wasp (Vespula). Component-resolved analysis with recombinant species-specific major allergens (rSSMA) may help to distinguish true double sensitization from crossreactivity. Included were 121 patients with systemic allergic reactions to Hymenoptera stings, 76 with double positivity of serum-specific IgE (sIgE) to both venoms, 45 with single positivity to bee or wasp venom, and 32 controls without history of systemic reactions to Hymenoptera stings and no sIgE to whole venoms. In venom-allergic patients and controls, sIgE to rSSMA Api m 1 of bee venom and to Ves v 1 and Ves v 5 of wasp venom were tested by ImmunoCAP. Only 47% of 76 patients with double positivity to whole venoms reacted also to rSSMA of both species. Specificity of sIgE to the 3 rSSMA was very high, with no sIgE to rSSMA of the other species in single-positive venom-allergic patients and only one control with low sIgE to Ves v 1. All wasp-allergic single-positive patients had sIgE to Ves v 5 and/or Ves v 1, and 78.3% of single-positive bee venom-allergic patients had sIgE to Api m 1. Specificity of sIgE to rSSMA of both species is excellent. Sensitivity of sIgE to rSSMA was optimal for wasp venom. Sensitivity of bee venom Api m 1 could be increased by adding rSSMA of other important bee venom allergens. © 2012 John Wiley & Sons A/S.
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            The venom of the Lonomia caterpillar: an overview.

            Contact with the Lonomia caterpillar causes numerous accidents, especially in Venezuela and the southern region of Brazil, where it is considered a public health problem. The Lonomia obliqua venom causes disseminated intravascular coagulation and a consumptive coagulopathy, which can lead to a hemorrhagic syndrome. The venom of Lonomia achelous also causes hemorrhage, but through increased fibrinolysis. In vivo and in vitro studies have shown that the venom of the Lonomia caterpillar contains several toxins with procoagulant, anticoagulant and antithrombotic activities. These toxins also affect the endothelium. The recent construction of cDNA libraries of the transcripts from L. obliqua bristles enables the use of biotechnological approaches to study the venom. This paper presents an overview of the biochemical and biological properties of Lonomia caterpillar venom, discussing aspects of human accidents, experimental envenomation, toxins and targets and future perspectives.
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              Effects of absence of saliva on blood feeding by mosquitoes.

              The salivary glands of Aedes stimulans (Walker) are the source of an antigen which produces typical bite reactions in men and laboratory rabbits. If the main salivary duct is cut, the reaction is not produced when the mosquito bites. Lack of saliva does not affect the intake or movement of blood into the mid-gut, nor does it prevent the development of eggs. The presence of ain a-nesthetic component in saliva is suggested.
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                Author and article information

                Journal
                Bioinformation
                Bioinformation
                Bioinformation
                Bioinformation
                Biomedical Informatics
                0973-2063
                2018
                22 December 2018
                : 14
                : 9
                : 540-553
                Affiliations
                [1 ]Department of Biochemistry, College of Medicine, University of Hail, Hail, Saudi Arabia, KSA
                Author notes
                [* ]Mohd Adnan Kausar adnankausar1@ 123456gmail.com
                Article
                97320630014540
                10.6026/97320630014540
                6563666
                31223213
                431d1ea6-fd69-4e7f-a561-aea6d84291e2
                © 2018 Biomedical Informatics

                This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.

                History
                : 3 December 2018
                : 20 December 2018
                : 20 December 2018
                Categories
                Review

                Bioinformatics & Computational biology
                allergens,respiratory allergy,insect allergens,mosquito allergens,ockroach allergens

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