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      SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

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      British Journal of Pharmacology and Chemotherapy

      Wiley

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          Abstract

          Various applications of pA(x) measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of pA(x) measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine-atropine, histamine-atropine and acetylcholine-cinchonidine. A new measure, pA(h), is introduced to express the activity of unsurmountable antagonists.

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          Most cited references 10

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          The Use of Chemical Potentials as Indices of Toxicity

           J. Ferguson (1939)
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            The antagonism of acetyl choline by atropine.

             A. J. Clark (1926)
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              QUANTITATIVE STUDIES OF ANTAGONISTS FOR 5-HYDROXYTRYPTAMINE

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                Author and article information

                Journal
                British Journal of Pharmacology and Chemotherapy
                Wiley
                03660826
                March 1959
                March 1959
                July 19 2012
                : 14
                : 1
                : 48-58
                Article
                10.1111/j.1476-5381.1959.tb00928.x
                1481829
                13651579
                © 2012

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