The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment.

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Abstract

To compare the efficacy and safety of adalimumab plus methotrexate (MTX) versus MTX monotherapy or adalimumab monotherapy in patients with early, aggressive rheumatoid arthritis (RA) who had not previously received MTX treatment.

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Journal

Journal ID (iso-abbrev): Arthritis Rheum

Title: Arthritis and rheumatism

Publisher: Wiley

ISSN: 0004-3591

ISSN (Print): 0004-3591

Publication date (Electronic): Jan 2006

Volume: 54

Issue: 1

Affiliations

[1 ] Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, C4-R Postbox 9600, Leiden 2300 RC, The Netherlands. f.c.breedveld@lumc.nl

Article

DOI: 10.1002/art.21519

PubMed ID: 16385520

SO-VID: 432fe6a0-06ff-4736-a6f8-ceb3cbf0c5b3

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