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      Comparative Analysis of Co-Processed Starches prepared by Three Different Methods


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          Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that co-granulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of co-processing influences the powder and tableting properties of the co-processed excipient.

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          Most cited references 49

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          Microcrystalline cellulose, a direct compression binder in a quality by design environment--a review.

          The ICH quality vision introduced the concept of quality by design (QbD), which requires a greater understanding of the raw material attributes, of process parameters, of their variability and their interactions. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Therefore excipients' variability and their impact on drug product performance need to be thoroughly understood. To help with this process, this review article gathers prior knowledge on MCC, focuses on its use in DC and lists some of its potential critical material attributes (CMAs).
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            An overview of the different excipients useful for the direct compression of tablets.

            The humble tablet dosage form still accounts for more than 80% of all dosage forms administered to man. This review will outline the various excipients that have been used as fillers in direct compression formulations, with particular emphasis on what is expected from such excipients in terms of their functionality. It is intended that this overview (which is by no means exhaustive) will serve as an 'aide-memoire' to the formulation scientist.
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              Density-pressure relationships in powder compaction


                Author and article information

                British Journal of Pharmacy
                University of Huddersfield Press
                01 November 2017
                : 2
                : 1
                : 55-69
                [1 ]Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University Zaria
                [2 ]Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development (NIPRD), Idu, Abuja
                [3 ]Gamlen Tableting Ltd, Biocity, Nottingham, UK
                Author notes
                *Corresponding author. Tel.: +234 8028283212 E-mail: pharmaroyi@ 123456yahoo.com
                © 2017, Y. E. Apeji, D. Aluga, O. J. Olayemi, C. Oparaeche, S. N. Anyebe, M. J. Gamlen, A. R. Oyi

                This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0 https://creativecommons.org/licenses/by/4.0/.

                Research Article


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