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      Regulatory T cells exhibit distinct features in human breast cancer

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          Summary

          Regulatory T (Treg) cells reside in lymphoid organs and barrier tissues where they control different types of inflammatory responses. Treg cells are also found in human cancers, and studies in animal models suggest that they contribute to cancer progression. However, properties of human intratumoral Treg cells and those present in corresponding normal tissue remain largely unknown. Here, we analyzed features of Treg cells in untreated human breast carcinomas, normal mammary gland, and peripheral blood. Tumor-resident Treg cells were potently suppressive and their gene expression pattern resembled that of normal breast tissue, but not of activated peripheral blood Treg cells. Nevertheless, a number of cytokine and chemokine receptor genes, most notably CCR8, were upregulated in tumor-resident Treg cells in comparison to normal tissue resident ones. Our studies suggest that targeting CCR8 for the depletion of tumor-resident Treg cells may represent a promising immunotherapeutic approach for the treatment of breast cancer.

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          Author and article information

          Journal
          9432918
          8591
          Immunity
          Immunity
          Immunity
          1074-7613
          1097-4180
          4 November 2016
          15 November 2016
          15 November 2017
          : 45
          : 5
          : 1122-1134
          Affiliations
          [1 ]Howard Hughes Medical Institute, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065
          [2 ]Immunology Program, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065
          [3 ]Ludwig Center at Memorial Sloan Kettering Cancer Center, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065
          [4 ]Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065
          [5 ]Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond VA 23298
          [6 ]Central European Institute of Technology, Brno, 60177, Czech Republic
          [7 ]Bioinformatics and Genomics Programme, Centre for Genomic Regulation Barcelona, 08003, Spain
          [8 ]Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997 Russia
          [9 ]Pirogov Russian National Research Medical University, Moscow, 117997, Russia
          Author notes
          [# ]Lead Contact: Alexander Y. Rudensky < rudenska@ 123456mskcc.org >
          [*]

          These authors contributed equally to this work.

          Article
          PMC5134901 PMC5134901 5134901 nihpa827501
          10.1016/j.immuni.2016.10.032
          5134901
          27851913
          433d0484-6041-48d4-ae6b-8a55218345a1
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