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      Mechanism of the Vasodilator Action of Pinacidil

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          Abstract

          The mechanism of the vasodilator action of pinacidil has been studied in rat mesenteric small arteries. The results show, first, that the use of flux studies to make measurements of ion permeability requires knowledge of the membrane potential, especially as regards K<sup>+</sup> permeability. Second, the results confirm that the vasodilator effect of pinacidil is due to an increase in K<sup>+</sup> permeability. Lastly, the results suggest that the K<sup>+</sup> channels involved are sensitive to glibenclamide.

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          Author and article information

          Journal
          Journal ID (publisher-id): JVR
          Journal ID (nlm-ta): J Vasc Res
          Journal ID (doi): 10.1159/issn.1018-1172
          Title: Journal of Vascular Research
          Publisher: S. Karger AG
          ISBN: 978-3-8055-5330-8
          ISBN: 978-3-318-01614-7
          ISSN (Print): 1018-1172
          ISSN (Electronic): 1423-0135
          Publication date Subscription-year: 1990
          Publication date (Print): 1990
          Publication date (Electronic): 23 September 2008
          Volume: 27
          Issue: 2-5
          Pages: 314-318
          Affiliations
          Danish Biomembrane Research Center and Department of Pharmacology, Aarhus University, Aarhus, Denmark
          Article
          Publisher ID: 158824 Other ID: Blood Vessels 1990;27:314–318
          DOI: 10.1159/000158824
          SO-VID: 435bc1cb-125f-4c98-a11b-64f7a14ac3a9
          Copyright © © 1990 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 5
          Categories
          Subject: Mechanisms of Vasodilatation

          ScienceOpen disciplines: General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Keywords: Resistance vessels,K+ channels,Membrane potential,Ion permeability
          Data availability:
          ScienceOpen disciplines: General medicine, Neurology, Cardiovascular Medicine, Internal medicine, Nephrology
          Keywords: Resistance vessels, K+ channels, Membrane potential, Ion permeability

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