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      Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.

      1 ,
      Nature reviews. Cancer
      Springer Nature

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          Abstract

          Solid tumours are an enormous cancer burden and a major therapeutic challenge. The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours. There is increasing evidence that diverse solid tumours are hierarchically organized and sustained by a distinct subpopulation of CSCs. Direct evidence for the CSC hypothesis has recently emerged from mouse models of epithelial tumorigenesis, although alternative models of heterogeneity also seem to apply. The clinical relevance of CSCs remains a fundamental issue but preliminary findings indicate that specific targeting may be possible.

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          Author and article information

          Journal
          Nat. Rev. Cancer
          Nature reviews. Cancer
          Springer Nature
          1474-1768
          1474-175X
          Oct 2008
          : 8
          : 10
          Affiliations
          [1 ] VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia. visvader@wehi.edu.au
          Article
          nrc2499
          10.1038/nrc2499
          18784658
          43689f8a-2d9d-40a2-808e-9b3c78c38395
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