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      Xenotransplantation: Perspectives and Limits

      Blood Purification

      S. Karger AG

      Xenotransplantation, Limits, Immunology, Virology, Species specificity, Ethics

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          Abstract

          Xenotransplantation faces the dilemma of an unlimited supply of cells, tissues and organs on the one hand and severe obstacles and limits on the other. One reason for the limitations is that the source animal of choice, the pig, and the human recipient separated 90 million years ago during evolution, a time in which biological characteristics such as anatomy, physiology and immunology have had much time to drift far apart. The acceptance of such an evolutionary widely divergent organ, especially the heart of a pig, could evoke refusal of xenotransplantation in conservative and religious patients. New legal aspects of allocation of xenografts have therefore to be reflected upon and appropriate guidelines developed. Inquiries show, however, that the acceptance of all types of porcine organs would be high if the quality of life after receiving such a xenograft is comparable to that after receiving the same allograft. This individual benefit of a xenograft could lead to a disregard of the collective risk in terms of xenozoonoses, often presented as a catastrophic scenarium. Therefore, transplantation societies and ethics committees have published comments and even guidelines for handling future clinical xenotransplantation. All three monotheistic religions and Hinduism support the idea of saving and improving human life with the help of an animal organ.

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          Most cited references 4

          • Record: found
          • Abstract: not found
          • Article: not found

          Search for Cross-Species Transmission of Porcine Endogenous Retrovirus in Patients Treated with Living Pig Tissue

           K Paradis (1999)
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Baboon-to-human liver transplantation

             J Fung,  T.E Starzl,  A Tzakis (1993)
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Baboon Bone Marrow Transplantation in Humans: Application of Cross-Species Disease Resistance

                Bookmark

                Author and article information

                Journal
                BPU
                Blood Purif
                10.1159/issn.0253-5068
                Blood Purification
                S. Karger AG
                0253-5068
                1421-9735
                2001
                2001
                26 February 2001
                : 19
                : 3
                : 322-328
                Affiliations
                Institute for Surgical Research, Ludwig Maximilians University Munich, Germany
                Article
                46961 Blood Purif 2001;19:322–328
                10.1159/000046961
                11244193
                © 2001 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                References: 34, Pages: 7
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/46961
                Categories
                Proceedings of the 18th ISBP Meeting

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