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Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer's disease.
R J Fontana
1 ,
T M deVries ,
T F Woolf ,
M J Knapp ,
A S Brown ,
L S Kaminsky ,
B K Tang ,
N L Foster ,
R R Brown ,
P B Watkins
Sep 1998
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Abstract
To study the potential utility of caffeine based probes of CYP1A2 enzyme activity in predicting the pharmokinetics of tacrine in patients with Alzheimer's disease.