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      Monitoring of dynamin during the Toxoplasma gondii cell cycle.

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          Abstract

          The obligate intracellular protozoan parasite Toxoplasma gondii actively invades virtually all warm-blooded nucleated cells. This process results in a non-fusogenic vacuole, inside which the parasites replicate continuously until egress signaling is triggered. In this work, we investigated the role of the large GTPase dynamin in the interaction of T. gondii with the host cell by using laser and electron microscopy during three key stages: invasion, development and egress. The detection of dynamin during invasion indicates the occurrence of endocytosis, while T. gondii egress appeared to be independent of dynamin participation. However, the presence of dynamin during T. gondii development suggests that this molecule plays undescribed roles in the tachyzoite's cell cycle.

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          Author and article information

          Journal
          Pathog Dis
          Pathogens and disease
          Oxford University Press (OUP)
          2049-632X
          2049-632X
          December 2016
          : 74
          : 9
          Affiliations
          [1 ] Instituto de Biofí-sica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil lucio@biof.ufrj.br.
          [2 ] Instituto Nacional de Metrologia Normalizacao e Qualidade Industrial, Duque de Caxias, RJ 25250-020, Brazil.
          [3 ] Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, 120 University Place Glasgow, Glasgow G12 8QQ, UK.
          [4 ] Microbiologia, UEZO, Av. Manuel Caldeira de Alvarenga, Rio de Janeiro, RJ 23070-200, Brazil.
          [5 ] Instituto de Biofí-sica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
          Article
          ftw108
          10.1093/femspd/ftw108
          27811048
          438ccefd-87dc-4656-879a-2729ee3a6120
          © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
          History

          Toxoplasma gondii,dynamin,host-pathogen interactions

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