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      Outbreak of Neisseria meningitidis, Edmonton, Alberta, Canada

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          Abstract

          From December 1999 to April 2001, the greater Edmonton region had 61 cases of invasive meningococcal infection, two fatal. The outbreak was due to Neisseria meningitidis serogroup C, electrophoretic type 15, serotype 2a. Analysis of the strains showed that 50 of 56 culture-confirmed cases were due to a single clone and close relatives of this clone. This strain had not been previously identified in the province of Alberta dating back to January 1997

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          Global epidemiology of meningococcal disease.

          Blake Moore, C V Broome, Austin Schwartz (1989)
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            Serogroup C meningococcal outbreaks in the United States. An emerging threat.

            A. Schuchat, Marina Reeves, Michael J. Wenger … (1995)
            Multiple outbreaks of serogroup C Neisseria meningitidis have recently been reported from diverse areas of the United States. To better define the characteristics of this increasingly important problem, we reviewed data on all known serogroup C outbreaks in the United States from January 1980 through June 1993. MEDLINE searches, Centers for Disease Control and Prevention records, state health department officials, infectious disease experts, and the meningococcal vaccine manufacturer. DEFINITION OF AN OUTBREAK: Three or more cases of serogroup C meningococcal disease within a 3-month period, either among members of a community or persons attending a single school or other institution, for which those cases represented an attack rate of at least five per 100,000 population. Twenty-one outbreaks of serogroup C meningococcal disease were identified; eight occurred since 1991. In 1992 and the first half of 1993, approximately 180,000 doses of vaccine were administered for outbreak control, compared with approximately 34,000 doses from 1980 to 1991. Approximately 50% of community-outbreak cases were between the ages of 5 and 24 years, compared with only 19% of sporadic serogroup C cases (P < .001). Subtyping of patient isolates indicates that outbreaks are clonal; however, at least five distinct but closely related strains have caused recent outbreaks. Serogroup C outbreaks are occurring more frequently in the United States. The effectiveness of preventive measures depends on early recognition; therefore, physicians should promptly report all cases of suspected meningococcal disease, and the causative serogroup should be established for every case.
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              Whole-cell ELISA for typingNeisseria meningitidiswith monoclonal antibodies

              Hussein Abdillahi, Jan Poolman (1987)
              Article 0 comments Cited 21 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Emerg Infect Dis
                Journal ID (iso-abbrev): Emerging Infect. Dis
                Journal ID (publisher-id): EID
                Title: Emerging Infectious Diseases
                Publisher: Centers for Disease Control and Prevention
                ISSN (Print): 1080-6040
                ISSN (Electronic): 1080-6059
                Publication date (Print): May 2002
                Volume: 8
                Issue: 5
                Pages: 519-521
                Affiliations
                [* ]The Provincial Laboratory of Public Health for Alberta, Alberta, Canada
                [† ]The University of Alberta, Edmonton, Alberta, Canada
                [‡ ]The Capital Health Authority, Edmonton, Alberta, Canada
                Author notes
                Address for correspondence: Gregory J. Tyrrell, Room 2B3.13 Walter Mackenzie Centre, The Provincial Laboratory for Public Health for Alberta, 8440-112 Street, Edmonton, Alberta T6G 2J2; fax: 780-407-3864; e-mail: g.tyrrell@ 123456provlab.ab.ca
                Article
                Publisher ID: 01-0337
                DOI: 10.3201/eid0805.010337
                PMC ID: 3393379
                PubMed ID: 11996690
                SO-VID: 438e9aa8-dd74-4668-861e-daaa5386c2db
                History
                Categories
                Subject: Dispatch
                Subject: Dispatch

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: neisseria meningitidis,pulsed-field gel electrophoresis,outbreak,serogroup c,canada,incidence
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                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: neisseria meningitidis, pulsed-field gel electrophoresis, outbreak, serogroup c, canada, incidence

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