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      Counting on natural products for drug design.

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          Abstract

          Natural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Recently, there has been a revitalization of interest in the inclusion of these chemotypes in compound collections for screening and achieving selective target modulation. Here we discuss natural-product-inspired drug discovery with a focus on recent advances in the design of synthetically tractable small molecules that mimic nature's chemistry. We highlight the potential of innovative computational tools in processing structurally complex natural products to predict their macromolecular targets and attempt to forecast the role that natural-product-derived fragments and fragment-like natural products will play in next-generation drug discovery.

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          Author and article information

          Journal
          Nat Chem
          Nature chemistry
          Springer Nature
          1755-4349
          1755-4330
          Jun 2016
          : 8
          : 6
          Affiliations
          [1 ] Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
          [2 ] inSili.com LLC, Segantinisteig 3, 8049 Zürich, Switzerland.
          Article
          nchem.2479
          10.1038/nchem.2479
          27219696
          4397b783-3c85-4bae-b1fe-dac84e4907b9
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