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MicroRNA-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cells.
Wan-Hsin Liu
1 ,
Shiou-Hwei Yeh ,
Cho-Chun Lu ,
Sung-Liang Yu ,
Hsuan-Yu Chen ,
Chien-Yu Lin ,
Ding-Shinn Chen ,
Pei-Jer Chen
Feb 2009
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Abstract
Men have a higher incidence of hepatocellular carcinoma (HCC) than women, which is believed to partly be because of protective effects of estrogen. We sought to determine whether there were differences in levels of microRNA (miRNA) molecules between male and female HCC samples.