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      Eurycoma Longifolia as a potential adoptogen of male sexual health: a systematic review on clinical studies

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          Abstract

          Eurycoma longifolia ( EL) has been well recognized as a booster of male sexual health. Over the past few decades, numerous in vivo animal studies and human clinical trials have been conducted across the globe to explore the promising role of EL in managing various male sexual disorders, which include erectile dysfunction, male infertility, low libido, and downregulated testosterone levels. The aim of the present review is to analyze and summarize the literature on human clinical trials which revealed the clinical significance and therapeutic feasibility of EL in improving male sexual health. This systematic review is focused on the following databases: Medline, Wiley Online Library, BioMed Central, Hindawi, Web of Knowledge, PubMed Central and Google Scholar, using search terms such as “ Eurycoma longifolia”, “ EL”, “Tongkat Ali”, “male sexual health”, “sexual infertility”, “erectile dysfunction”, “male libido”, and “testosterone levels”. Notably, only human clinical studies published between 2000 and 2014 were selected and thoroughly reviewed for relevant citations. Out of 150 articles, 11 met the inclusion criteria. The majority of articles included were randomized placebo-controlled trials, multiple cohort studies, or pilot trials. All these studies demonstrated considerable effects of EL on male sexual health disorders. Among them, 7 studies revealed remarkable association between the use of EL and the efficacy in the treatment of male sexual disorders, and remaining 4 studies failed to demonstrate sufficient effects on male sexual health. In summary, there is convincing evidence for the prominence of EL in improving the male sexual health. The review also substantiates the use of current methodology in the development of novel and more rationale natural herbal medicines for the management of male sexual disorders.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 January 2017
          : 15
          : 1
          : 71-80
          Affiliations
          1Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia (The National University of Malaysia), Jalan Yaacob Latif 56000, Malaysia
          2Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam 42300, Malaysia
          Author notes
          *Corresponding author: Ahmad Nazrun Shuid, Tel: +6(0)391459567; Fax: +6(0)291459547; E-mail: anazrun@ 123456yahoo.com

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(17)30010-9
          10.1016/S1875-5364(17)30010-9
          28259255
          Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Ministry of Agriculture for providing New Application for Herbal Research Grant Scheme (NRGS)
          Award ID: NH1014D040
          This work was supported by the Ministry of Agriculture for providing New Application for Herbal Research Grant Scheme (NRGS) (No. NH1014D040).

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