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Sudden infant death syndrome: increased carotid-body dopamine and noradrenaline content.

Lancet

physiopathology, Carotid Body, analysis, Dopamine, Epinephrine, Female, Humans, Infant, Infant, Newborn, Male, Norepinephrine, Respiration, Sudden Infant Death, metabolism

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      Abstract

      Carotid bodies from infants dying of sudden infant death syndrome contained significantly higher concentrations of dopamine (10-fold) and noradrenaline (3-fold) than those from age-matched control infants. Administration of dopamine inhibits respiration by direct action on the carotid body, and it is suggested that the elevated levels of endogenous catecholamines found in victims of sudden infant death syndrome may compromise the normal function of the carotid body, particularly the ventilatory response to hypoxia.

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      6147601

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