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      Outcome of Immediate Versus Early Antibiotics in Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis.

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          Abstract

          Debate exists about the mortality benefit of administering antibiotics within either 1 or 3 hours of sepsis onset. We performed this meta-analysis to analyze the effect of immediate (0 to 1 hour after onset) versus early (1 to 3 hours after onset) antibiotics on mortality in patients with severe sepsis or septic shock.

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          Author and article information

          Journal
          Ann Emerg Med
          Annals of emergency medicine
          Elsevier BV
          1097-6760
          0196-0644
          October 2020
          : 76
          : 4
          Affiliations
          [1 ] Department of Emergency Medicine, Dr. P Phillips Hospital, Orlando Health, Orlando, FL; Residency in Emergency Medicine, Orlando Health, Orlando, FL; Florida State University College of Medicine, Tallahassee, FL.
          [2 ] Department of Emergency Medicine, Orlando Regional Medical Center, Orlando Health, Orlando, FL; Residency in Emergency Medicine, Orlando Health, Orlando, FL.
          [3 ] Section Acute Medicine, Department of Internal Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands; Center for Experimental and Molecular Medicine, Amsterdam UMC, Academic Medical Center, University Medical Center, Amsterdam, the Netherlands.
          [4 ] Florida State University College of Medicine, Tallahassee, FL.
          [5 ] Section Acute Medicine, Department of Internal Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands.
          Article
          S0196-0644(20)30337-1
          10.1016/j.annemergmed.2020.04.042
          32593430
          43b22dc9-df52-40b6-b388-a2c24e703dad

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