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      CRISPR/Cas9 gene-editing: Research technologies, clinical applications and ethical considerations

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      Seminars in Perinatology

      Elsevier BV

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          Abstract

          Gene therapy carries the potential to treat more than 10,000 human monogenic diseases and benefit an even greater number of complex polygenic conditions. The repurposing of CRISPR/Cas9, an ancient bacterial immune defense system, into a gene-editing technology has armed researchers with a revolutionary tool for gene therapy. However, as the breadth of research and clinical applications of this technology continues to expand, outstanding technical challenges and ethical considerations will need to be addressed before clinical applications become commonplace. Here, we review CRISPR/Cas9 technology and discuss its benefits and limitations in research and the clinical context, as well as ethical considerations surrounding the use of CRISPR gene editing.

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          Author and article information

          Journal
          Seminars in Perinatology
          Seminars in Perinatology
          Elsevier BV
          01460005
          December 2018
          December 2018
          : 42
          : 8
          : 487-500
          Article
          10.1053/j.semperi.2018.09.003
          30482590
          © 2018

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