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      Corpse clearance defines the meaning of cell death.

      1 ,
      Nature
      Springer Science and Business Media LLC

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          Abstract

          While philosophers seek the meaning of life, cell biologists are becoming ever more interested in the meaning of death. Apoptosis marks unwanted cells with 'eat me' signals that direct recognition, engulfment and degradation by phagocytes. Far from being the end of the story, these clearance events allow scavenger cells to confer meaning upon cell death. But if the phagocytic 'spin doctors' receive or transmit the wrong messages, trouble ensues.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          0028-0836
          0028-0836
          Oct 12 2000
          : 407
          : 6805
          Affiliations
          [1 ] University of Edinburgh/Medical Research Council Centre for Inflammation Research, Department of Clinical and Surgical Sciences, Internal Medicine, Royal Infirmary, UK. j.savill@ed.ac.uk
          Article
          10.1038/35037722
          11048729
          43fb165b-1b2e-4c70-bd4e-d47e03ed434e
          History

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