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      UV Light-Responsive Peptide-Based Supramolecular Hydrogel for Controlled Drug Delivery

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          Hydrogels for tissue engineering.

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            Designing hydrogels for controlled drug delivery

            Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable physical properties, controllable degradability and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. In this Review, we cover multiscale mechanisms underlying the design of hydrogel drug delivery systems, focusing on physical and chemical properties of the hydrogel network and the hydrogel-drug interactions across the network, mesh, and molecular (or atomistic) scales. We discuss how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation. We also collect experimental release data from the literature, review clinical translation to date of these systems, and present quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
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              Is Open Access

              Hydrogel: Preparation, characterization, and applications: A review

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                Author and article information

                Contributors
                (View ORCID Profile)
                (View ORCID Profile)
                Journal
                Macromolecular Rapid Communications
                Macromol. Rapid Commun.
                Wiley
                10221336
                December 2018
                December 2018
                October 01 2018
                : 39
                : 24
                : 1800588
                Affiliations
                [1 ]School of Chemistry, Faculty of Exact Sciences; Tel Aviv University; Tel Aviv 69978 Israel
                [2 ]Department of Oral Biology; The Goldschleger School of Dental Medicine; Sackler Faculty of Medicine; Tel Aviv University; Tel Aviv 69978 Israel
                Article
                10.1002/marc.201800588
                30276909
                43fb96f3-7a20-44b5-9137-cdb89023aab5
                © 2018

                http://doi.wiley.com/10.1002/tdm_license_1.1

                http://onlinelibrary.wiley.com/termsAndConditions#vor

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