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      Disorder-specific genetic factors in obsessive-compulsive disorder: A comprehensive meta-analysis

      American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

      Wiley-Blackwell

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          Most cited references 28

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          Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

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            Rothstein HR

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              Candidate gene studies of ADHD: a meta-analytic review.

              Quantitative genetic studies (i.e., twin and adoption studies) suggest that genetic influences contribute substantially to the development of attention deficit hyperactivity disorder (ADHD). Over the past 15 years, considerable efforts have been made to identify genes involved in the etiology of this disorder resulting in a large and often conflicting literature of candidate gene associations for ADHD. The first aim of the present study was to conduct a comprehensive meta-analytic review of this literature to determine which candidate genes show consistent evidence of association with childhood ADHD across studies. The second aim was to test for heterogeneity across studies in the effect sizes for each candidate gene as its presence might suggest moderating variables that could explain inconsistent results. Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25. Further, significant heterogeneity was observed for the associations between ADHD and DAT1, DRD4, DRD5, DBH, ADRA2A, 5HTT, TPH2, MAOA, and SNAP25, suggesting that future studies should explore potential moderators of these associations (e.g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). We conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD.
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                Author and article information

                Journal
                American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
                Am. J. Med. Genet.
                Wiley-Blackwell
                15524841
                April 2016
                April 30 2016
                : 171
                : 3
                : 325-332
                Article
                10.1002/ajmg.b.32407
                © 2016

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