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      • Record: found
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      Macular Hole following Intravitreal Bevacizumab Injection in Choroidal Neovascularization Caused by Age-Related Macular Degeneration

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          Abstract

          This report describes formation of a full-thickness macular hole subsequent to an injection of bevacizumab for the treatment of neovascular AMD. This complication may be caused by focal tractional forces on the retinal surface due to either vitreous incarceration at the injection site or contraction of the choroidal neovascularization membrane. Alternatively, it may be due to a toxic effect of bevacizumab on a previously compromised retina.

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          Age-related macular degeneration is the leading cause of blindness...

          Neil Bressler (2004)
          Article 0 comments Cited 185 times – based on 0 reviews     Review now
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            Characteristics of severe intraocular inflammation following intravitreal injection of bevacizumab (Avastin).

            M Georgopoulos, F Prager, U Schmidt … (2009)
            To report a series of severe intraocular inflammatory events following intravitreal injections of bevacizumab (Avastin). This procedure is performed on a rapidly increasing number worldwide, and rare complications such as intraocular inflammation, endophthalmitis or intraocular haemorrhage are gaining in importance in clinical routine. This is a single-centre retrospective interventional case series of eight patients with severe intraocular inflammation after intravitreal injection of bevacizumab at one referral centre consecutively seen out of approximately a total of 2500 injections performed in that time period. Patients who developed severe intraocular inflammation after intravitreal injection were evaluated clinically, including slit-lamp examination, best-corrected Snellen visual acuity (VA), slit-lamp photography, optical coherence tomography and fluorescein angiography prior to the event and during follow-up. Patients noticed a painless drop in VA up to 2 days following the injection. All patients had a marked anterior chamber reaction with increased flare and cells, but no hypopyon. Typical posterior segment findings included vitreous cellular infiltrates of pseudogranulomatous aspect. Due to their initial clinical aspect suspicious of an endophthalmitis, three cases were treated with systemic antibiotics, but the final diagnosis was uveitis. Five cases showed a characteristic pseudogranulomatous vitreous infiltration as seen in vitritis and were treated only topically. Characteristic features of an inflammation induced by bevacizumab injection include an early onset with painless loss in VA mostly without conjunctival or ciliary injection. Patients respond to systemic or topical cortisone treatment with slow recovery but without permanent damage. Vitreous haemorrhage and infectious endophthalmitis might be differentiated by time course and symptoms.
            Article 0 comments Cited 26 times – based on 0 reviews     Review now
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              Macular hole following intravitreal ranibizumab injection for choroidal neovascular membrane caused by age-related macular degeneration.

              E Souied, Giuseppe Querques, Gisèle Soubrane (2009)
              Article 0 comments Cited 16 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Case Report Ophthalmol
                Journal ID (publisher-id): COP
                Title: Case Reports in Ophthalmology
                Publisher: S. Karger AG (Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch )
                ISSN (Electronic): 1663-2699
                Publication date Collection: May-Aug 2010
                Publication date (Electronic): 18 August 2010
                Volume: 1
                Issue: 1
                Pages: 36-41
                Affiliations
                [1] aDepartments of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
                [2] bSheba Medical Center, Tel Hashomer; both affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
                Author notes
                *Elad Moisseiev, MD, Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Weitzman 6 St., Tel Aviv, 64239 (Israel), Tel. +972 3 697 3408, Fax +972 3 697 3870, E-Mail elad_moi@ 123456netvision.net.il
                Article
                Publisher ID: cop0001-0036
                DOI: 10.1159/000319827
                PMC ID: 2969161
                PubMed ID: 21369348
                SO-VID: 4415876a-4b91-4867-8e37-497777efd50f
                Copyright © Copyright © 2010 by S. Karger AG, Basel
                History
                Page count
                Figures: 2, References: 12, Pages: 6
                Categories
                Subject: Published: August 2010

                ScienceOpen disciplines: Ophthalmology & Optometry
                Keywords: intravitreal injection,age-related macular degeneration,choroidal neovascularization,bevacizumab,macular hole
                Data availability:
                ScienceOpen disciplines: Ophthalmology & Optometry
                Keywords: intravitreal injection, age-related macular degeneration, choroidal neovascularization, bevacizumab, macular hole

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