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      Dynamics and diversity in autophagy mechanisms: lessons from yeast.

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          Abstract

          Autophagy is a fundamental function of eukaryotic cells and is well conserved from yeast to humans. The most remarkable feature of autophagy is the synthesis of double membrane-bound compartments that sequester materials to be degraded in lytic compartments, a process that seems to be mechanistically distinct from conventional membrane traffic. The discovery of autophagy in yeast and the genetic tractability of this organism have allowed us to identify genes that are responsible for this process, which has led to the explosive growth of this research field seen today. Analyses of autophagy-related (Atg) proteins have unveiled dynamic and diverse aspects of mechanisms that underlie membrane formation during autophagy.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0080
          1471-0072
          Jul 2009
          : 10
          : 7
          Affiliations
          [1 ] Integrated Research Institute, Tokyo Institute of Technology, Yokohama 2268503, Japan.
          Article
          nrm2708
          10.1038/nrm2708
          19491929
          4422c571-1227-4656-a4d3-c9dc39730815
          History

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