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      Potent effect of adenoviral vector expressing short hairpin RNA targeting ribonucleotide reductase large subunit M1 on cell viability and chemotherapeutic sensitivity to gemcitabine in non-small cell lung cancer cells.

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          Abstract

          Ribonucleotide reductase large subunit (RRM1) is the main enzyme responsible for synthesis of the deoxyribonucleotides used during DNA synthesis. It is also a cellular target for gemcitabine (GEM). Overexpression of RRM1 is reportedly associated with resistance to GEM and the poor prognosis for many types of malignant tumours. Aim of the present study is to establish gene therapy against RRM1-overexpressing tumours.

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          Author and article information

          Journal
          Eur. J. Cancer
          European journal of cancer (Oxford, England : 1990)
          Elsevier BV
          1879-0852
          0959-8049
          Nov 2015
          : 51
          : 16
          Affiliations
          [1 ] Department of General Thoracic Surgery, Faculty of Medicine, Kagawa University, 1750-1, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
          [2 ] Department of General Thoracic Surgery, Faculty of Medicine, Kagawa University, 1750-1, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. Electronic address: dgliu@kms.ac.jp.
          [3 ] Department of Urology, Faculty of Medicine, Kagawa University, 1750-1, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
          [4 ] Kitano Hospital, Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan.
          Article
          S0959-8049(15)00444-X
          10.1016/j.ejca.2015.05.013
          26254808
          442806a9-666c-4de1-8d3e-1e9bdf65e5ec
          History

          Chemotherapeutic sensitivity,Gemcitabine,Gene therapy,RRM1,shRNA,Adenovirus

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