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      Ascorbate-Cyanide Test on Red Blood Cells in Uremia: Effect of Guanidinopropionic Acid

      research-article
      , , ,
      Nephron
      S. Karger AG
      Uremia, Erythrocytes, Sulfhemoglobin

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          Abstract

          Red blood ceils (RBC) of uremic or control subjects have been exposed to an oxidative stress by ascorbate and cyanide. The spectrophotometric determination of the sulfhemoglobin production has been used as a reliable method for the measurement of the hexose monophosphate shunt. The sulfhemoglobin production by RBC was significantly higher in uremic than in control subjects. Uremic plasma increased this production in uremic as well as in control RBC while control plasma was ineffective under the same conditions. In vitro the guanidinopropionic acid had the same toxic effect on normal RBC. These results suggest that the abnormal sulfhemoglobin production by uremic RBC might be due to an increased plasma concentration of guanidinopropionic acid in uremia.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1981
          1981
          02 December 2008
          : 28
          : 1
          : 26-29
          Affiliations
          Laboratoire de Biochimie Génétique, Clinique néphrologique and U25, INSERM Hôpital Necker, Paris, France
          Article
          182089 Nephron 1981;28:26–29
          10.1159/000182089
          7266724
          444934bc-95fd-444b-9872-a43975f5316e
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 16 September 1980
          Page count
          Pages: 4
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          Uremia,Erythrocytes,Sulfhemoglobin
          Cardiovascular Medicine, Nephrology
          Uremia, Erythrocytes, Sulfhemoglobin

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