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      Altered Erythrocyte Sodium Efflux following Renal Transplantation

      , ,

      Nephron

      S. Karger AG

      Sodium transport, Renal transplant, Erythrocyte, Sodium efflux, Uremia

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          Abstract

          Abnormalities of membrane sodium transport are one of the manifestations of chronic renal failure. Following correction of the renal failure by renal transplantation erythrocyte membrane NaK ATPase activity increases to supranormal values. In the present study, direct measurements of erythrocyte sodium efflux were performed in 21 renal transplant patients. The mean rate constant for total sodium efflux was increased from 0.40 ± 0.01 in a group of control subjects to 0.45 ± 0.02 in the transplant patients (p < 0.02). This increase in the total sodium efflux rate constant was attributable to an increase in the glycoside sensitive component of sodium efflux which averaged 0.26 ± 0.01 in the control subjects, compared to 0.32 ± 0.02 in the transplant patients (p < 0.01). Intracellular sodium was significantly lower in the patients (5.8 ± 0.3 mmol/l of erythrocytes) than it was in the controls (7.5 ± 0.2 mmol/l of erythrocytes). Overall pump flux was not increased in the renal transplant patients, suggesting that a new steady state had been established in their erythrocytes, with the red cell sodium set at a new level. When normal erythrocytes were preincubated with the plasma of renal transplant patients, all components of sodium efflux remained normal. The plasma of renal transplant patients also was ineffective in inducing a change in cell membrane NaK ATPase activity in vitro. It is concluded that following renal transplantation there are changes in erythrocyte sodium transport, which are the obverse of those seen in uremia. Although further studies will be necessary before a pharmacologic explanation for these changes can be ruled out, it is possible that they represent overcompensation in a transport system previously exposed to prolonged uremic suppression.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1978
          1978
          02 December 2008
          : 20
          : 5
          : 248-257
          Affiliations
          Medical and Transplant Services, Royal Victoria Hospital, Department of Medicine, McGill University, Montreal, Que.
          Article
          181230 Nephron 1978;20:248–257
          10.1159/000181230
          148009
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 10
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Sodium transport, Renal transplant, Erythrocyte, Sodium efflux, Uremia

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