5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Synthesis of ursolic acid arylidene-hydrazide hybrid compounds and investigation of their cytotoxic and antimicrobial effects

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references38

          • Record: found
          • Abstract: found
          • Article: not found

          Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

          Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018 database, compiled and disseminated by the International Agency for Research on Cancer (IARC). This paper reviews the sources and methods used in compiling the cancer statistics in 185 countries. The validity of the national estimates depends upon the representativeness of the source information, and to take into account possible sources of bias, uncertainty intervals are now provided for the estimated sex- and site-specific all-ages number of new cancer cases and cancer deaths. We briefly describe the key results globally and by world region. There were an estimated 18.1 million (95% UI: 17.5-18.7 million) new cases of cancer (17 million excluding non-melanoma skin cancer) and 9.6 million (95% UI: 9.3-9.8 million) deaths from cancer (9.5 million excluding non-melanoma skin cancer) worldwide in 2018.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Cancer statistics for the year 2020: An overview

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Natural products as sources of new drugs over the last 25 years.

              This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003. In the case of all approved agents the time frame has been extended to include the 251/2 years from 01/1981 to 06/2006 for all diseases worldwide and from 1950 (earliest so far identified) to 06/2006 for all approved antitumor drugs worldwide. We have continued to utilize our secondary subdivision of a "natural product mimic" or "NM" to join the original primary divisions. From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well. Thus, in the area of cancer, over the time frame from around the 1940s to date, of the 155 small molecules, 73% are other than "S" (synthetic), with 47% actually being either natural products or directly derived therefrom. In other areas, the influence of natural product structures is quite marked, with, as expected from prior information, the antiinfective area being dependent on natural products and their structures. Although combinatorial chemistry techniques have succeeded as methods of optimizing structures and have, in fact, been used in the optimization of many recently approved agents, we are able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame. We wish to draw the attention of readers to the rapidly evolving recognition that a significant number of natural product drugs/leads are actually produced by microbes and/or microbial interactions with the "host from whence it was isolated", and therefore we consider that this area of natural product research should be expanded significantly.
                Bookmark

                Author and article information

                Contributors
                Journal
                Natural Product Research
                Natural Product Research
                Informa UK Limited
                1478-6419
                1478-6427
                August 03 2023
                March 11 2022
                August 03 2023
                : 37
                : 15
                : 2500-2507
                Affiliations
                [1 ]Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Bezmialem Vakif University, Turkey
                [2 ]Faculty of Pharmacy, Bezmialem Vakif University, Turkey
                [3 ]Faculty of Medicine, Department of Biophysics, Bezmialem Vakif University, Turkey
                [4 ]Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Bezmialem Vakif University, Turkey
                Article
                10.1080/14786419.2022.2051170
                35275500
                4478f020-6ebc-4fd0-b37e-5fa8b7e9b14f
                © 2023
                History

                Comments

                Comment on this article

                scite_

                Similar content2,154

                Cited by10

                Most referenced authors517