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      [The effects of gastrojejunostomy for patients with advanced gastric cancer accompanied by peritoneal dissemination].

      Gan to kagaku ryoho. Cancer & chemotherapy
      Aged, Aged, 80 and over, Antimetabolites, Antineoplastic, therapeutic use, Drug Combinations, Female, Gastric Bypass, Gastric Outlet Obstruction, surgery, Humans, Male, Middle Aged, Oxonic Acid, Palliative Care, Peritoneal Neoplasms, secondary, Stomach Neoplasms, drug therapy, pathology, Tegafur, Treatment Outcome

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          Abstract

          We evaluated the efficacy of gastrojejunostomy for advanced gastric cancer patients with peritoneal dissemination. We evaluated the clinical outcome of 11 patients (average age 73.5 years for 8 men) who received gastrojejunostomy for gastric outlet obstruction caused by advanced gastric cancer with peritoneal dissemination between October 2003 and December 2008. We performed stomach-partitioning gastrojejunistomy with tube jejunostomy. Three patients with performance status 3 and severe peritoneal dissemination deteriorated during the early postoperative days and were transferred to terminal care. These three patients died after 23, 26 and 60 days. The other 8 patients were discharged from hospital between 10 and 35 days postoperatively (median hospital stay 16 days) and received chemotherapy with S-1 on an outpatient basis. All patients died within one year except the one who showed a partial response to chemotherapy and lived for 40 months (MST: 8 months in all patients). It seemed that there was little adaptation to gastrogejunostomy as palliation surgery for patients with poor performance status (PS 3) and severe peritoneal dissemination.

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