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      The Role of the Transcription Factor CREB in Immune Function

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          Abstract

          CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element. Several immune-related genes possess this cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-α. In addition, phosphorylated CREB has been proposed to directly inhibit NF-κB activation by blocking the binding of CREB binding protein to the NF-κB complex, thereby limiting proinflammatory responses. CREB also induces an antiapoptotic survival signal in monocytes and macrophages. In T and B cells, CREB activation promotes proliferation and survival and differentially regulates Th1, Th2, and Th17 responses. Finally, CREB activation is required for the generation and maintenance of regulatory T cells. This review summarizes current advances involving CREB in immune function—a role that is continually being defined.

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          Author and article information

          Journal
          2985117R
          4816
          J Immunol
          J. Immunol.
          Journal of immunology (Baltimore, Md. : 1950)
          0022-1767
          1550-6606
          19 April 2011
          01 December 2010
          20 July 2017
          : 185
          : 11
          : 6413-6419
          Affiliations
          [* ]Division of Pediatric Critical Care, University of California Los Angeles, Los Angeles, CA, 90095
          []Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of California Los Angeles, Los Angeles, CA, 90095
          []Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095
          Author notes
          Address correspondence and reprint requests to: Lloyd S. Miller, Division of Dermatology, Department of Medicine, University of California Los Angeles, 52-121 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095. lloydmiller@ 123456mednet.ucla.edu
          Article
          PMC5519339 PMC5519339 5519339 nihpa288074
          10.4049/jimmunol.1001829
          5519339
          21084670
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          Article

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