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      Coupling between physiological TSPO expression in brain and myocardium allows stabilization of late-phase cerebral [18F]GE180 PET quantification

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          Abstract

          PET imaging of the 18 kDa translocator protein (TSPO), a biomarker of microglial activity, receives growing interest in clinical and preclinical applications of neuroinflammatory and neurodegenerative brain diseases. In globally affected brains, intra-cerebral pseudo reference regions are not feasible. Consequently, many brain-independent approaches have been attempted, including SUV analysis and normalization to muscle- or heart uptake, aiming to stabilize quantitative analysis. In this study, we systematically compared different image normalization methods for static late phase TSPO-PET imaging of rodent brain.

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          Author and article information

          Journal
          NeuroImage
          NeuroImage
          Elsevier BV
          10538119
          January 2018
          January 2018
          : 165
          : 83-91
          Article
          10.1016/j.neuroimage.2017.10.006
          28988133
          44acf1a5-7e95-455a-8a61-bff5fa3a2a24
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

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