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      In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer (68)Ga-NOTA-c(NGR).

      1 , 1 , 2 , 2 , 3 , 4 , 1 , 3 , 1 , 4 , 1 , 5
      European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
      Elsevier BV
      (68)Ga-NODAGA-[c(RGD)](2), (68)Ga-NOTA-c(NGR), (Benzotriazol-1-yloxy)tris(dimethylamino) phosphonium, 1-Hydroxybenzotriazole (HOBt) (PubChem CID: 2796029), 14,7-Triazacyclononane-1,4,7-triacetic acid (NOTA) (PubChem CID: 3036142), Aminopeptidase N (CD13) expression, Dimethylformamide (DMF) (PubChem CID: 6228), Glyicine (PubChem CID: 750), Hexafluorophosphate (PubChem CID: 151348), N-diisopropylethylamine (DIEA) (PubChem CID: 81531), Positron emission tomography, Renal tumors, Trifluoroacetic acid (TFA) (PubChem CID: 6422), Triisopropylsilane (TIS) (PubChem CID: 6327611), Tumor angiogenesis, l-Arginine (PubChem CID: 6322), l-Asparagine (PubChem CID: 6267), l-Glutamic acid (PubChem CID: 33032), l-Lysine (PubChem CID: 5962)

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          Abstract

          Aminopeptidase N (APN/CD13) plays an important role in tumor neoangiogenic process and the development of metastases. Furthermore, it may serve as a potential target for cancer diagnosis and therapy. Previous studies have already shown that asparagine-glycine-arginine (NGR) peptides specifically bind to APN/CD13. The aim of the study was to synthesize and investigate the APN/CD13 specificity of a novel (68)Ga-labeled NOTA-c(NGR) molecule in vivo using miniPET.

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          Author and article information

          Journal
          Eur J Pharm Sci
          European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
          Elsevier BV
          1879-0720
          0928-0987
          Mar 10 2015
          : 69
          Affiliations
          [1 ] Department of Nuclear Medicine, University of Debrecen, Hungary.
          [2 ] MTA-ELTE, Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Eötvös L. University, Budapest, Hungary.
          [3 ] Department of Periodontology, University of Debrecen, Debrecen, Hungary.
          [4 ] Department of Physiology, University of Debrecen, Debrecen, Hungary.
          [5 ] Department of Nuclear Medicine, University of Debrecen, Hungary; Scanomed LTD, Debrecen, Hungary. Electronic address: trencsenyi.gyorgy@med.unideb.hu.
          Article
          S0928-0987(15)00004-4
          10.1016/j.ejps.2015.01.002
          25592229
          44b10e9a-e182-44da-ae14-b84dae82092e
          History

          l-Lysine (PubChem CID: 5962),Tumor angiogenesis,l-Arginine (PubChem CID: 6322),l-Asparagine (PubChem CID: 6267),l-Glutamic acid (PubChem CID: 33032),(68)Ga-NODAGA-[c(RGD)](2),(68)Ga-NOTA-c(NGR),(Benzotriazol-1-yloxy)tris(dimethylamino) phosphonium,1-Hydroxybenzotriazole (HOBt) (PubChem CID: 2796029),14,7-Triazacyclononane-1,4,7-triacetic acid (NOTA) (PubChem CID: 3036142),Aminopeptidase N (CD13) expression,Dimethylformamide (DMF) (PubChem CID: 6228),Glyicine (PubChem CID: 750),Hexafluorophosphate (PubChem CID: 151348),N-diisopropylethylamine (DIEA) (PubChem CID: 81531),Positron emission tomography,Renal tumors,Trifluoroacetic acid (TFA) (PubChem CID: 6422),Triisopropylsilane (TIS) (PubChem CID: 6327611)

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