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      Crystal structure of IFIT2 (ISG54) predicts functional properties of IFITs.

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      Cell research

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          Abstract

          Interferon carries out its cellular effects, including its antiviral effects, by inducing the synthesis of many new proteins, amongst which is the IFIT (ISG56) family of proteins. The first crystal structure of an IFIT, reported by Yang et al., revealed several functional properties of the protein that may help us to better understand the biological functions of these proteins.

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          Author and article information

          Journal
          Cell Res.
          Cell research
          1748-7838
          1001-0602
          Oct 2012
          : 22
          : 10
          Affiliations
          [1 ] Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, OH 44195, USA. seng@ccf.org
          Article
          cr2012130
          10.1038/cr.2012.130
          3463260
          22964712

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