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      Inhibition of pancreatic tumoral cells by snake venom disintegrins.

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          Abstract

          Pancreatic cancer often has a poor prognosis, even when diagnosed early. Pancreatic cancer typically spreads rapidly and is rarely detected in its early stages, which is a major reason it is a leading cause of cancer death. Signs and symptoms may not appear until pancreatic cancer is quite advanced, and complete surgical removal is not possible. Furthermore, pancreatic cancer responds poorly to most chemotherapeutic agents. The importance of integrins in several cell types that affect tumor progression has made them an appealing target for cancer therapy. Some of the proteins found in the snake venom present a great potential as anti-tumor agents. In this study, we summarize the activity of two integrins antagonist, recombinant disintegrins mojastin 1 and viridistatin 2, on human pancreatic carcinoma cell line (BXPC-3). Both recombinant disintegrins inhibited some essential aspects of the metastasis process such as proliferation, adhesion, migration, and survival through apoptosis, making these proteins prominent candidates for the development of drugs for the treatment of pancreatic cancer.

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          Author and article information

          Journal
          Toxicon
          Toxicon : official journal of the International Society on Toxinology
          1879-3150
          0041-0101
          Jan 2015
          : 93
          Affiliations
          [1 ] National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX, 78363, USA.
          [2 ] Biology Department, Del Mar College, 101 Baldwin Blvd., Corpus Christi, TX, 78404, USA.
          [3 ] National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX, 78363, USA; Department of Chemistry, Texas A&M University-Kingsville, MSC 161, Kingsville, TX, 78363, USA. Electronic address: elda.sanchez@tamuk.edu.
          Article
          S0041-0101(14)00599-6 NIHMS647460
          10.1016/j.toxicon.2014.11.228
          4278407
          25450798
          44ce2bca-fcf8-437e-89b7-587707b66469
          Copyright © 2014 Elsevier Ltd. All rights reserved.
          History

          Cancer therapy,Disintegrins,Integrins antagonist,Pancreatic cancer

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