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      The HLA-IDDM association: Implications for etiology and pathogenesis of IDDM

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      Diabetes / Metabolism Reviews

      Wiley

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          Most cited references 8

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          Interleukin-1

           C A Dinarello (1984)
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            Insulin-Dependent Diabetes Mellitus

             J Bertrams,  M P Baur (1985)
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              HLA associations in insulin-dependent diabetes: search for heterogeneity in different groups of patients from a homogeneous population

              A total of 317 unrelated Danish patients with insulin-dependent diabetes mellitus (IDDM) have been HLA-DR typed and the antigen and phenotype frequencies compared with those in 1177 unrelated Danish controls. The strong positive associations with DR3 and 4 and the strong negative one with DR2 were confirmed, and the remaining antigens showed a hierarchy from weakly positive to strongly negative associations: DRw9, w8, 1, 5, w6, 7. The study population included various special groups of patients selected in order to study heterogeneity: very early (less than 5 years) and very late (greater than 40 years) onset IDDM, pregnancy-induced IDDM, IDDM nephropathy, and long-term (greater than 40 years) survivors without complications. When comparing these groups, the following minor differences were seen: the DR3,4 phenotype is significantly (p = .02) more frequent in IDDM with onset before age 20 (35%) than in other cases (24%), and in familial IDDM (48%) than in other cases (28%); the frequency of the DR4 antigen was significantly (p = .008) more frequent in long-term survivors (86%) than in other patients (69%), while it was significantly (p = .02) less frequent in IDDM nephropathy (63%) than in long-term survivors. However, apart from the age-at-onset heterogeneity, which was suspected a priori, these differences may be due to chance, and the main conclusion of this study is that the HLA-DR associations in IDDM are indeed extraordinarily homogeneous irrespective of the clinical characteristics at onset and course of the disease.
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                Author and article information

                Journal
                DMR
                Diabetes / Metabolism Reviews
                Diabetes Metab. Rev.
                Wiley
                07424221
                10990895
                July 1987
                July 1987
                : 3
                : 3
                : 779-802
                Article
                10.1002/dmr.5610030309
                © 1987
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